Description

2-[1-(4-Nitrophenyl)-2-(2,4,5-Trimethoxyphenyl)Vinyl]-(5H)-Oxazole-4,4-Dimethanol Hydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. This compound is a critical building block in the synthesis of advanced antiviral and antiretroviral active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation therapeutics targeting viral infections.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for non-nucleoside reverse transcriptase inhibitor (NNRTI) class antiviral drugs.
• Antiretroviral Drug Synthesis: Essential in the manufacturing process for APIs used in HIV/AIDS treatment regimens.
• Antiviral Research: Serves as a crucial reference standard and starting material in medicinal chemistry for developing new antiviral agents.
• Process Chemistry & Scale-Up: Used in process development and optimization for commercial-scale API production under GMP guidelines.
• Biochemical Research: Employed in biochemical assays and studies to understand the mechanism of action of NNRTIs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	2-[1-(4-Nitrophenyl)-2-(2,4,5-Trimethoxyphenyl)Vinyl]-(5H)-Oxazole-4,4-Dimethanol Hydrochloride
CAS No.	93777-61-8
Molecular Formula	C22H22N2O7 · HCl
Molecular Weight	470.88 g/mol (Free base: 434.43 g/mol)
Synonyms	2-[1-(4-Nitrophenyl)-2-(2,4,5-Trimethoxyphenyl)Ethenyl]-(5H)-Oxazole-4,4-Dimethanol Hydrochloride; NNRTI Intermediate; 4,4-Bis(hydroxymethyl)-2-[2-(4-nitrophenyl)-1-(2,4,5-trimethoxyphenyl)ethenyl]-4,5-dihydrooxazole Hydrochloride; Oxazole Dimethanol Derivative Hydrochloride; CAS 93777-61-8; Antiviral Intermediate 93777-61-8
EINECS	Contact for details

Quality Control

Our 2-[1-(4-Nitrophenyl)-2-(2,4,5-Trimethoxyphenyl)Vinyl]-(5H)-Oxazole-4,4-Dimethanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets the stringent requirements for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.