Description

2-Iodomelatonin is a chemically modified analog of the endogenous hormone melatonin, distinguished by the introduction of an iodine atom at the 2-position of the indole ring. This structural modification is critical for research applications, particularly in the development of high-affinity radioligands for receptor binding studies. It serves as a key intermediate and reference standard in pharmaceutical research, neuroscience, and endocrinology. This compound is essential for scientists and manufacturers focused on studying melatonin receptor subtypes, signal transduction pathways, and developing novel therapeutic agents.

Application

• Pharmaceutical Research & Development: As a crucial intermediate in the synthesis of novel melatonin receptor agonists and antagonists for therapeutic exploration.
• Biochemical Tool Compound: Used in the development of iodinated radioligands (e.g., 125I-labeled) for melatonin receptor binding assays and autoradiography studies.
• Neuroscience Studies: A reference standard for investigating the structure-activity relationships (SAR) of melatonin analogs and their effects on circadian rhythms and sleep.
• Academic & Institutional Research: Employed in basic scientific research to elucidate melatoninergic signaling pathways and receptor pharmacology.
• Chemical Synthesis: Serves as a versatile building block for further chemical modifications to create specialized probes and labeled compounds.
• Quality Control & Analytical Standards: Used as a certified reference material (CRM) for method development and validation in analytical laboratories.

Basic Information

Product Name	2-Iodomelatonin
CAS No.	93515-00-5
Molecular Formula	C13H15IN2O2
Molecular Weight	358.18 g/mol
Synonyms	N-[2-(5-Iodo-1H-indol-3-yl)ethyl]acetamide; 2-Iodo-5-methoxy-N-acetyltryptamine; ML-23; Iodomelatonin; 5-Methoxy-2-iodotryptamine acetate; 2-I-MLT
EINECS	Contact for details

Quality Control

Our 2-Iodomelatonin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurities is provided with every shipment. We support research and development with material suitable for use as a reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.