Description

4-Hydroxy-5,7-Bis-Trifluoromethyl-Quinoline-3-Carboxylic Acid Ethyl Ester is a high-value, fluorinated quinoline derivative that serves as a critical synthetic intermediate in advanced chemical synthesis. Its molecular structure, featuring multiple trifluoromethyl groups, imparts unique electronic and steric properties essential for developing compounds with enhanced biological activity and material performance. This specialty chemical is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, particularly for targets requiring fluorinated motifs to improve metabolic stability, bioavailability, and binding affinity.
• Agrochemical Research: Used in developing advanced pesticides and herbicides, where the introduction of fluorine atoms can lead to products with higher potency and environmental selectivity.
• Material Science Precursor: Serves as a monomer or functional additive in the research of specialty polymers and organic electronic materials, leveraging its fluorinated aromatic system.
• Chemical Synthesis Scaffold: Utilized in organic chemistry R&D for constructing complex heterocyclic compounds and libraries for high-throughput screening.
• Ligand and Catalyst Development: Acts as a precursor for creating novel chelating ligands or organocatalysts used in asymmetric synthesis and metal-catalyzed reactions.

Basic Information

Product Name	4-Hydroxy-5,7-Bis-Trifluoromethyl-Quinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	93514-83-1
Molecular Formula	C₁₅H₉F₆NO₃
Molecular Weight	365.23 g/mol
Synonyms	Ethyl 4-hydroxy-5,7-bis(trifluoromethyl)quinoline-3-carboxylate; 5,7-Bis(trifluoromethyl)-4-hydroxyquinoline-3-carboxylic acid ethyl ester; 4-Hydroxy-5,7-di(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester; Quinoline-3-carboxylic acid, 4-hydroxy-5,7-bis(trifluoromethyl)-, ethyl ester; Ethyl 4-hydroxy-5,7-di(trifluoromethyl)-3-quinolinecarboxylate
EINECS	Contact for details

Quality Control

Our production of 4-Hydroxy-5,7-Bis-Trifluoromethyl-Quinoline-3-Carboxylic Acid Ethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested against established specifications, which typically include identity confirmation by spectroscopic methods, purity assay by HPLC, and control of specific impurities. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.