Description

2-Keto-4,4,4-Trifluorobutyl Phosphate is a specialized organofluorine phosphate ester compound with significant utility as a key synthetic intermediate. Its value lies in the unique reactivity imparted by the trifluoromethyl ketone group adjacent to the phosphate moiety, enabling precise chemical modifications. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical sectors for constructing complex molecules, particularly in the synthesis of fluorinated active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides where the introduction of fluorine atoms enhances biological activity and environmental stability.
• Chemical Research: Serves as a versatile reagent in organic synthesis for introducing phosphate and trifluoromethyl ketone functional groups into target molecules.
• Material Science: Potential precursor for creating specialized fluorinated polymers or surface-modifying agents with unique properties.
• Bioconjugation Chemistry: May be employed in the development of probes or linkers for modifying biomolecules due to its reactive phosphate group.

Basic Information

Product Name	2-Keto-4,4,4-Trifluorobutyl Phosphate
CAS No.	93383-53-0
Molecular Formula	C4H6F3O5P
Molecular Weight	222.06 g/mol
Synonyms	4,4,4-Trifluoro-3-oxobutyl Dihydrogen Phosphate; 3-Oxo-4,4,4-trifluorobutyl Phosphate; 4,4,4-Trifluoroacetoacetyl Phosphate; (4,4,4-Trifluoro-3-oxobutyl)phosphate; TFAP; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of 2-Keto-4,4,4-Trifluorobutyl Phosphate adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Quality is verified through comprehensive analytical techniques including NMR, HPLC, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.