Description

Naloxone Methiodide CAS NO 93302-47-7 is a quaternary ammonium salt derivative of the opioid antagonist naloxone. This compound is a critical research chemical and reference standard used primarily in pharmacological studies to investigate opioid receptor mechanisms. It serves as a vital tool for scientists and pharmaceutical developers working on neuropharmacology and analgesic research. Its primary value lies in its ability to act as a peripherally restricted opioid antagonist, making it essential for differentiating central from peripheral opioid effects.

Application

• Pharmacological Research: A key reference standard for in vitro and in vivo studies of opioid receptor antagonism.
• Neuroscience Studies: Used to investigate the role of peripheral opioid receptors in pain modulation and other physiological processes.
• Drug Discovery & Development: Serves as a critical tool compound for screening and characterizing new opioid-based therapeutics.
• Biochemical Assays: Employed in receptor binding assays and functional studies to determine antagonist potency and selectivity.
• Academic Research: Utilized in university and institutional labs for fundamental research on the opioid system.
• Metabolism and Toxicology Studies: Acts as a probe to understand the metabolic pathways and effects of opioid antagonists.

Basic Information

Product Name	Naloxone Methiodide
CAS No.	93302-47-7
Molecular Formula	C₂₁H₂₆INO₄
Molecular Weight	507.34 g/mol
Synonyms	Naloxone Methyl Iodide; Naloxone Methoiodide; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one methiodide; Naloxonium Methiodide; Naloxone Quaternary Ammonium Salt; Naloxone N-Methyl Iodide; MRZ 2663 BR; Methylnaloxone Iodide
EINECS	Contact for details

Quality Control

Our Naloxone Methiodide is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling. A Certificate of Analysis (COA) detailing specific results for parameters such as HPLC purity, residual solvents, and heavy metals is provided with every shipment to support your compliance and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.