Description

Benzo[A]Pyrene-7-14C is a carbon-14 radiolabeled analog of the well-known polycyclic aromatic hydrocarbon (PAH), benzo[a]pyrene. This isotopically labeled compound is an essential tool for advanced research, enabling precise metabolic, environmental, and toxicological studies through traceable detection. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, environmental science, and chemical analysis sectors to investigate bioactivation pathways, environmental fate, and DNA adduct formation.

Application

• Metabolic Pathway Tracing: Used as a radiotracer in in vitro and in vivo studies to elucidate the metabolic activation and detoxification routes of benzo[a]pyrene.
• Environmental Fate Studies: Employed in research to track the degradation, bioaccumulation, and transport of PAHs in soil, water, and air samples.
• Toxicology and Carcinogenicity Research: A critical reagent for studying the mechanisms of DNA damage, mutagenesis, and carcinogenesis associated with PAH exposure.
• Analytical Method Development: Serves as an internal standard or reference material in the development and validation of highly sensitive analytical methods like LC-MS/MS or accelerator mass spectrometry (AMS).
• Biomarker Discovery: Used to identify and quantify specific benzo[a]pyrene-DNA or protein adducts as biomarkers of exposure and effect.
• Pharmaceutical Research: Applied in drug discovery to study the inhibition of cytochrome P450 enzymes involved in PAH metabolism.

Basic Information

Product Name	Benzo[A]Pyrene-7-14C
CAS No.	93127-18-5
Molecular Formula	C20H12 (with 14C at the 7-position)
Molecular Weight	~252.3 g/mol (exact mass depends on specific activity)
Synonyms	7-14C-Benzo[a]pyrene; B[a]P-7-14C; 3,4-Benzpyrene-7-14C; Benzo[a]pyrene-7-14C; Benzpyrene-7-14C; 1,2-Benzpyrene-7-14C; 3,4-Benz[a]pyrene-7-14C; BAP-7-14C
EINECS	Contact for details

Quality Control

Every batch of Benzo[A]Pyrene-7-14C is manufactured and analyzed under strict quality protocols to ensure identity, purity, and specific activity. Our quality control includes rigorous testing via HPLC with radiometric detection and spectroscopic methods. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the specific activity (mCi/mmol or GBq/mmol), radiochemical purity, chemical purity, and solvent information.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. For long-term storage, solutions are recommended to be kept under inert atmosphere to prevent decomposition. Handle and dispose of in accordance with all applicable radiation safety regulations and guidelines.

Specification

Item	Specification
Appearance	Yellow to Brown Solution or Solid
Identification (HPLC, MS)	Conforms to Standard
Specific Activity	Customizable (e.g., 50-60 mCi/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent	Toluene, Benzene, or other specified
Concentration	Customizable (e.g., 1.0 mCi/mL)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.