Description

1-[4-(Methylsulfonyl)-2-Nitrophenyl]Pyrrolidine-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrolidine carboxylic acid scaffold linked to a methylsulfonyl nitrophenyl moiety. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel drug candidates targeting complex biological pathways. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly those exploring pyrrolidine-based structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Protease Inhibitor Development: Serves as a precursor or core structure in the research of inhibitors for various enzymes, leveraging its carboxylic acid functionality.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target validation.
• Custom Synthesis & Scale-Up: Supplied for custom manufacturing projects, from milligram-scale research to kilogram-scale pilot production for clinical trials.
• Academic Research: Used in university and institutional laboratories for advanced organic synthesis and pharmaceutical science projects.

Basic Information

Product Name	1-[4-(Methylsulfonyl)-2-Nitrophenyl]Pyrrolidine-2-Carboxylic Acid
CAS No.	93001-20-8
Molecular Formula	C₁₂H₁₄N₂O₆S
Molecular Weight	314.31 g/mol
Synonyms	2-Pyrrolidinecarboxylic acid, 1-[4-(methylsulfonyl)-2-nitrophenyl]-; 1-(4-Methanesulfonyl-2-nitrophenyl)pyrrolidine-2-carboxylic acid; (S)-1-(4-(Methylsulfonyl)-2-nitrophenyl)pyrrolidine-2-carboxylic acid; L-Proline, 1-[4-(methylsulfonyl)-2-nitrophenyl]-; 93001-20-8; Pyrrolidine-2-carboxylic acid, 1-[4-(methylsulfonyl)-2-nitrophenyl]-; 1-(4-Methylsulfonyl-2-nitrophenyl)-2-pyrrolidinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 1-[4-(Methylsulfonyl)-2-Nitrophenyl]Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.