Description

(S)-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid CAS NO 92976-98-2 is a high-value, non-proteinogenic amino acid derivative featuring a chiral tetrahydroquinoline scaffold. This compound is a critical chiral building block in modern organic synthesis, prized for its ability to introduce stereochemical complexity and a rigid, fused-ring structure into target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other biologically active molecules.
• Agrochemical Research: Used in the development of novel herbicides and pesticides with enhanced stereospecific activity.
• Peptidomimetics & Drug Design: Serves as a constrained amino acid analog to improve metabolic stability and binding affinity in peptide-based drug candidates.
• Asymmetric Catalysis: Employed as a chiral ligand precursor or auxiliary in enantioselective synthesis.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Material Science: A potential monomer for creating novel polymers with specific optical or electronic properties.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid
CAS No.	92976-98-2
Molecular Formula	C10H11NO2
Molecular Weight	177.20 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-2-quinolinecarboxylic Acid; (S)-THQCA; (S)-2-Carboxy-1,2,3,4-tetrahydroquinoline; (S)-1,2,3,4-Tetrahydroquinoline-2-carboxylic acid; L-1,2,3,4-Tetrahydroquinoline-2-carboxylic acid; (2S)-1,2,3,4-Tetrahydroquinoline-2-carboxylic acid; (S)-Tic-OH analog
EINECS	Contact for details

Quality Control

Our (S)-1,2,3,4-Tetrahydro-Quinoline-2-Carboxylic Acid is manufactured under strict quality management systems. We provide material with typical chiral purity exceeding 99% ee and chemical purity >98%, verified by HPLC and chiral HPLC analysis. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and residual solvent content are provided with each batch to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.