Description

D-Histidine, Methyl Ester, Monohydrochloride is a protected derivative of the essential amino acid L-Histidine, where the carboxylic acid group is esterified and the compound is isolated as a hydrochloride salt. This modification enhances its stability and solubility in organic media, making it a crucial chiral building block and intermediate in sophisticated synthetic pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptides, bioactive molecules, and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the asymmetric synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) for incorporating modified histidine residues into peptide sequences.
• Biochemical Research: Employed as a standard or reagent in enzymatic studies, metabolic pathway analysis, and proteomics research.
• Agrochemical Development: Acts as an intermediate in the synthesis of specialized amino acid-based compounds for crop protection products.
• Diagnostic Reagent Manufacturing: Utilized in the production of reagents and kits for clinical diagnostics and biochemical assays.

Basic Information

Item	Detail
Product Name	D-Histidine, Methyl Ester, Monohydrochloride
CAS No.	92742-29-5
Molecular Formula	C7H12N3O2 • HCl
Molecular Weight	215.65 g/mol
Synonyms	D-Histidine methyl ester hydrochloride; (R)-1-Methyl 2-amino-3-(1H-imidazol-4-yl)propanoate hydrochloride; Methyl D-histidinate hydrochloride; D-Histidine O-methyl ester hydrochloride; Histidine methyl ester D-form hydrochloride; Methyl (R)-2-amino-3-(1H-imidazol-5-yl)propanoate hydrochloride; D-Histidine Me ester HCl
EINECS	Contact for details

Quality Control

Our D-Histidine, Methyl Ester, Monohydrochloride is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to ensure full traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.