Description

4-Methylene-1,3-Dioxaspiro[4.5]Decan-2-One is a specialized spirocyclic compound featuring a unique molecular architecture that combines a dioxolane ring with a cyclohexane-derived spiro system. This structure makes it a valuable and versatile building block in advanced organic synthesis, particularly for creating complex molecules with specific stereochemistry and functional group arrays. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Used in the research and development of new generation pesticides and herbicides, where its spirocyclic core can contribute to unique biological activity.
• Fine Chemical Building Block: Employed in the construction of complex natural product analogs, flavors, fragrances, and advanced material precursors.
• Academic & Industrial R&D: A critical reagent for methodological studies in organic chemistry, including cycloaddition reactions and asymmetric catalysis research.
• Material Science: Investigated as a monomer or cross-linking agent for developing polymers with specific thermal or optical properties.

Basic Information

Product Name	4-Methylene-1,3-Dioxaspiro[4.5]Decan-2-One
CAS No.	92474-80-1
Molecular Formula	C10H14O3
Molecular Weight	182.22 g/mol
Synonyms	4-Methylene-1,3-dioxaspiro[4.5]decan-2-one; 2-Oxo-4-methylene-1,3-dioxaspiro[4.5]decane; 4-Methylenespiro[1,3-dioxolane-2,1'-cyclohexan]-2-one; Spiro[1,3-dioxolane-2,1'-cyclohexan]-2-one, 4-methylene-; MDD (abbreviation); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 4-Methylene-1,3-Dioxaspiro[4.5]Decan-2-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay purity and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.