Description

Thp-Peg12 is a specialized polyethylene glycol derivative featuring a tetrahydropyranyl (THP) protecting group. This compound is a crucial intermediate in organic synthesis and bioconjugation, valued for its solubility-enhancing and linker properties. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as drug delivery system development and polymer modification.

Application

• Pharmaceutical Intermediates: Serves as a key building block and protecting group reagent in the synthesis of complex active pharmaceutical ingredients (APIs).
• Bioconjugation & PEGylation: Acts as a heterobifunctional linker for attaching therapeutic molecules (e.g., peptides, proteins) to polyethylene glycol (PEG) chains to improve pharmacokinetics.
• Polymer Chemistry: Used as a functional monomer or initiator in the synthesis of specialized, water-soluble copolymers and hydrogels.
• Drug Delivery Systems: Incorporated into the design of micelles, liposomes, and nanoparticles to enhance drug solubility, stability, and targeted release.
• Surface Modification: Employed to functionalize surfaces and materials with hydrophilic PEG layers to reduce non-specific binding and improve biocompatibility.
• Crosslinking Agent: Utilized in the preparation of crosslinked networks for controlled-release formulations and biomaterial scaffolds.

Basic Information

Product Name	Thp-Peg12
CAS No.	92417-25-9
Molecular Formula	C27H54O13 (Typical for THP-PEG12-OH)
Molecular Weight	~586.7 g/mol
Synonyms	THP-PEG12-OH; Tetrahydropyranyl-PEG12-alcohol; 2-(2-(2-(2-(2-(2-(2-(2-(2-(2-(2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethanol; α-Hydro-ω-(tetrahydro-2H-pyran-2-yloxy)-poly(oxy-1,2-ethanediyl); Polyethylene glycol monothp ether (n~12); THP-protected PEG12 alcohol; PEG12 THP ether
EINECS	Contact for details

Quality Control

Our Thp-Peg12 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as identity, assay, and impurity profiles. We support compliance with cGMP, ISO, and other relevant quality standards for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight Distribution (GPC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.