Description

Boc-Tyr(Po3Bzl2)-Oh is a protected phosphotyrosine derivative, specifically a benzyl-protected phosphonate analog of Boc-Tyrosine. This compound is a critical building block in peptide synthesis and medicinal chemistry research, enabling the study of phosphotyrosine-dependent signaling pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of kinase inhibitors, phosphopeptide mimetics, and other therapeutic agents targeting protein-protein interactions.

Application

• Phosphopeptide Synthesis: A key intermediate for the solid-phase or solution-phase synthesis of peptides containing phosphotyrosine or its non-hydrolyzable analogs.
• Medicinal Chemistry Research: Used in the design and development of peptidomimetics, kinase inhibitors, and signal transduction modulators.
• Biochemical Probe Development: Serves as a precursor for creating labeled or tagged probes to study protein phosphorylation, SH2 domain interactions, and other phosphotyrosine-mediated biological processes.
• Pharmaceutical Intermediate: Employed in the research and development stages of novel therapeutic candidates targeting cancer, metabolic disorders, and immune diseases.
• Chemical Biology Tool: Facilitates the study of enzyme mechanisms and substrate specificity for phosphatases and kinases.

Basic Information

Product Name	Boc-Tyr(Po3Bzl2)-Oh
CAS No.	92265-01-5
Molecular Formula	C₂₇H₂₈NO₈P
Molecular Weight	525.49 g/mol
Synonyms	Boc-O-(Di(benzyloxy)phosphoryl)-L-tyrosine; N-(tert-Butoxycarbonyl)-O-[bis(benzyloxy)phosphoryl]tyrosine; Boc-Tyr(PO(OBzl)₂)-OH; Boc-L-Tyrosine(PO(OBzl)₂); tert-Butyloxycarbonyl-O-(dibenzylphosphono)-L-tyrosine; Boc-Tyr(PO₃Bzl₂)-OH; (2S)-3-(4-{[Bis(benzyloxy)phosphoryl]oxy}phenyl)-2-[(tert-butoxycarbonyl)amino]propanoic acid
EINECS	Contact for details

Quality Control

Our Boc-Tyr(Po3Bzl2)-Oh is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for the manufacture of pharmaceutical intermediates, and our quality systems are designed to meet the stringent requirements of global research and development partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.