Description

3”-o-Demethyl Ivermectin is a key intermediate and metabolite in the synthesis and metabolic pathway of the broad-spectrum antiparasitic agent Ivermectin. This compound matters for researchers and manufacturers focused on developing and analyzing next-generation anthelmintic and acaricidal agents, as it provides critical insights into metabolic activity and degradation pathways. It is primarily needed by the pharmaceutical R&D sector, agrochemical research laboratories, and analytical service providers specializing in veterinary medicine and parasitology.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of Ivermectin and its metabolites in biological matrices and pharmaceutical formulations.
• Metabolic Pathway Studies: Serves as a critical intermediate in research investigating the biotransformation and pharmacokinetics of Ivermectin in target organisms.
• Agrochemical Research: Employed in the development and efficacy testing of novel endectocide compounds and formulations for animal health.
• Analytical Method Development: Essential for calibrating equipment and validating analytical methods such as HPLC and LC-MS/MS in quality control laboratories.
• Process Chemistry Intermediate: Utilized in the synthetic pathway for producing specialized Ivermectin derivatives or for impurity profiling in API manufacturing.

Basic Information

Product Name	3”-o-Demethyl Ivermectin
CAS No.	92137-95-6
Molecular Formula	C₄₇H₇₂O₁₄
Molecular Weight	861.1 g/mol
Synonyms	3''-O-Desmethyl Ivermectin; 3''-O-Demethylivermectin; 3''-Desmethyl Ivermectin; Ivermectin 3''-O-Desmethyl; 22,23-Dihydroavermectin B1a 3''-O-desmethyl; 5-O-Demethyl-22,23-dihydroavermectin A1a; 3''-O-Demethyl-22,23-dihydroavermectin B1a
EINECS	Contact for details

Quality Control

Our 3”-o-Demethyl Ivermectin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.