Description

Milbemycin B, 5-o-Demethyl-28-Deoxy-6,28-Epoxy-23-(Methoxyimino)-25-(1-Methyl-1-Butenyl)-, [6R,23E,25S(E)]- (9Ci) is a high-purity, semi-synthetic derivative of the milbemycin family of macrolide compounds. This advanced intermediate is critical for the research and development of novel acaricidal and anthelmintic agents, offering a key building block for creating next-generation animal health and crop protection solutions. It is primarily sought by R&D scientists and process chemists in the pharmaceutical and agrochemical industries for synthesis and biological activity studies.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of advanced milbemycin-based insecticides and acaricides for crop protection.
• Veterinary Pharmaceutical Research: Used in the development of new anthelmintic and anti-parasitic formulations for livestock and companion animals.
• Chemical Synthesis: Serves as a sophisticated starting material or intermediate for the preparation of structurally complex macrolide derivatives.
• Biological Activity Studies: Employed in biochemical and pharmacological research to investigate structure-activity relationships (SAR) within the milbemycin class.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in manufacturing and regulatory testing.
• Process Development & Scale-up: Supports optimization and validation of synthetic routes for the commercial production of milbemycin analogs.

Basic Information

Product Name	Milbemycin B, 5-o-Demethyl-28-Deoxy-6,28-Epoxy-23-(Methoxyimino)-25-(1-Methyl-1-Butenyl)-, [6R,23E,25S(E)]- (9Ci)
CAS No.	114041-23-5
Molecular Formula	C₃₃H₄₇NO₇
Molecular Weight	569.73 g/mol
Synonyms	5-O-Demethyl-28-deoxy-6,28-epoxy-23-(methoxyimino)-25-[(1E)-1-methyl-1-buten-1-yl]milbemycin B; 23-(Methoxyimino)milbemycin B derivative; 5-O-Desmethyl-28-deoxy-6,28-epoxy-23-(methoxyimino)-25-(1-methyl-1-butenyl)milbemycin B; [6R-[6R*,23E,25S*(E)]]-5-O-Demethyl-28-deoxy-6,28-epoxy-23-(methoxyimino)-25-(1-methyl-1-butenyl)milbemycin B; Milbemycin B oxime derivative; (9CI) Milbemycin B, 5-o-demethyl-28-deoxy-6,28-epoxy-23-(methoxyimino)-25-(1-methyl-1-butenyl)-, [6R,23E,25S(E)]-
EINECS	Contact for details

Quality Control

Our Milbemycin B derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting standards for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.