Description

(1S,2R,8R,8Ar)-1,2,8-Triacetoxy-Octahydro-5-Oxyindolizine is a high-purity, stereochemically defined indolizine derivative, serving as a critical advanced intermediate in complex organic synthesis. Its precise stereochemistry and functional group array make it an invaluable building block for pharmaceutical research and development, particularly in the synthesis of bioactive alkaloids and complex chiral molecules. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce sophisticated molecular architectures with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in alkaloid-based therapeutics.
• Asymmetric Synthesis: Utilized as a sophisticated building block in stereoselective reactions to construct complex natural products and their analogs.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs targeting neurological or infectious diseases.
• Process Chemistry Development: Serves as a benchmark or starting material for scaling up synthetic routes to complex molecules under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Synthesis: Potential intermediate in the development of advanced, chiral crop protection agents with specific modes of action.
• Academic & Institutional Research: Used in universities and research institutes for methodological development in total synthesis and catalysis.

Basic Information

Product Name	(1S,2R,8R,8Ar)-1,2,8-Triacetoxy-Octahydro-5-Oxyindolizine
CAS No.	91897-68-6
Molecular Formula	C15H21NO7
Molecular Weight	327.33 g/mol
Synonyms	1,2,8-Tri-O-acetyl-5-hydroxyindolizidine; Octahydro-5-hydroxyindolizine-1,2,8-triyl triacetate; (1S,2R,8R,8aR)-1,2,8-Triacetoxy-5-oxo-octahydroindolizine; 5-Oxoindolizidine-1,2,8-triyl triacetate; Triacetyloxyoctahydrooxyindolizine; 91897-68-6; Indolizine triacetate derivative
EINECS	Contact for details

Quality Control

Our (1S,2R,8R,8Ar)-1,2,8-Triacetoxy-Octahydro-5-Oxyindolizine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, enantiomeric excess, and impurity profiles. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.