Description

2-Amino-4,4,4-Trifluoro-n-Butyric Acid Hydrochloride is a high-purity, non-natural amino acid derivative characterized by its trifluoromethyl group, which imparts unique physicochemical properties. This compound is a critical building block in medicinal chemistry and agrochemical research, where the introduction of fluorine atoms is used to modulate bioactivity, metabolic stability, and lipophilicity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated drug candidates, including protease inhibitors and enzyme modulators.
• Agrochemical Research: Used in the synthesis of novel herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Peptide Chemistry: Serves as a specialized, fluorinated amino acid residue for constructing modified peptides with altered conformational and binding properties.
• Biochemical Tool Compound: Employed in metabolic pathway studies and as a probe to investigate enzyme-substrate interactions involving fluorinated analogs.
• Material Science Precursor: Acts as a starting material for synthesizing fluorinated ligands and functional molecules used in advanced materials.

Basic Information

Product Name	2-Amino-4,4,4-Trifluoro-n-Butyric Acid Hydrochloride
CAS No.	91291-66-6
Molecular Formula	C4H7F3NO2 • HCl
Molecular Weight	197.56 g/mol
Synonyms	2-Amino-4,4,4-trifluorobutanoic acid hydrochloride; 4,4,4-Trifluoro-DL-norvaline hydrochloride; DL-4,4,4-Trifluoronorvaline hydrochloride; 2-Amino-4,4,4-trifluorobutyric acid HCl; (±)-2-Amino-4,4,4-trifluorobutanoic acid hydrochloride; 4,4,4-Trifluoronorvaline HCl; (RS)-2-Amino-4,4,4-trifluorobutanoic acid hydrochloride
EINECS	Contact for details

Quality Control

Our production of 2-Amino-4,4,4-Trifluoro-n-Butyric Acid Hydrochloride adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and elemental analysis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment, supporting compliance with cGMP and ISO 9001 standards for research and commercial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed and under an inert atmosphere if opened, to prevent degradation from absorbed moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Optical Purity (Chiral HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.