Description

3-Hydroxy-2-(Toluene-4-Sulfonylamino)-Butyric Acid is a specialized organic compound that serves as a valuable chiral building block and synthetic intermediate in advanced chemical synthesis. Its molecular structure, featuring both hydroxy and sulfonylamino functional groups, makes it a critical precursor for the development of complex, high-value molecules. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and fine chemical sectors for applications requiring precise stereochemistry and functional group manipulation.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for compounds targeting specific biological pathways.
• Peptidomimetic Synthesis: Used in the construction of peptide analogs and mimetics, where the sulfonylamino group can act as a surrogate for peptide bonds or introduce novel bioactivity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the synthesis of chiral ligands used in asymmetric hydrogenation and other enantioselective transformations.
• Protease Inhibitor Development: Employed in the design and synthesis of potential enzyme inhibitors, leveraging its structural similarity to transition-state analogs.
• Fine Chemical Production: Acts as a building block for creating specialty chemicals with applications in agrochemicals and advanced material science.
• Academic & Industrial Research: A valuable tool for methodological development in organic synthesis and medicinal chemistry research programs.

Basic Information

Product Name	3-Hydroxy-2-(Toluene-4-Sulfonylamino)-Butyric Acid
CAS No.	91280-33-0
Molecular Formula	C11H15NO5S
Molecular Weight	273.31 g/mol
Synonyms	2-[(4-Methylphenyl)sulfonyl]amino-3-hydroxybutyric acid; 3-Hydroxy-2-[(4-tolylsulfonyl)amino]butanoic acid; 2-(p-Toluenesulfonamido)-3-hydroxybutyric acid; N-(p-Tolylsulfonyl)-3-hydroxy-2-aminobutyric acid; 3-Hydroxy-2-(tosylamino)butyric acid; (2R,3S)-2-[(4-Methylphenyl)sulfonylamino]-3-hydroxybutyric acid (for specific stereoisomer); TSA-HBA
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-2-(Toluene-4-Sulfonylamino)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with detailed Certificates of Analysis (COA), which include data from HPLC, NMR, and chiral purity assays. Specifications can be aligned with research-grade or GMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for specific isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.