Description

trans-4-Phenyl-L-Proline Hydrochloride is a high-purity, non-proteinogenic amino acid derivative widely used as a critical chiral building block in pharmaceutical synthesis. Its rigid, substituted proline scaffold is essential for modulating peptide conformation and enhancing metabolic stability in drug candidates. This compound is particularly valuable for research and development chemists in the pharmaceutical and biotechnology sectors working on novel therapeutics, including protease inhibitors and GPCR-targeted molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system disorders and cardiovascular diseases.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational constraints into peptide backbones, improving bioavailability and receptor selectivity in drug design.
• Organocatalyst Development: Serves as a precursor or core structure for developing novel asymmetric organocatalysts used in stereoselective synthesis.
• Biochemical Research: Employed in academic and industrial research to study enzyme-substrate interactions, protein folding, and structure-activity relationships (SAR).
• Ligand Synthesis for Metal Complexes: Utilized in the preparation of specialized ligands for catalytic metal complexes used in cross-coupling and other organic transformations.

Basic Information

Product Name	trans-4-Phenyl-L-Proline Hydrochloride
CAS No.	90657-53-7
Molecular Formula	C₁₁H₁₃NO₂·HCl
Molecular Weight	227.69 g/mol
Synonyms	(2S,4R)-4-Phenylpyrrolidine-2-carboxylic acid hydrochloride; L-Proline, 4-phenyl-, hydrochloride, (4R)-; trans-4-Phenyl-L-proline HCl; (4R)-4-Phenyl-L-proline hydrochloride; 4-Phenyl-L-proline hydrochloride (trans); Fmoc-Tic-OH (related protected form); 4-PhPro-OH·HCl
EINECS	Contact for details

Quality Control

Our trans-4-Phenyl-L-Proline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.