Description

1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 90604-02-7. This compound is valued for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in novel drug development and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates targeting neurological disorders.
• API Synthesis: Used in the production route of complex Active Pharmaceutical Ingredients (APIs), particularly those containing the azetidine pharmacophore.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable manufacturing processes for clinical and commercial drug supply.
• Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under current Good Manufacturing Practice (cGMP) standards.

Basic Information

Product Name	1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride
CAS No.	90604-02-7
Molecular Formula	C16H18ClNO
Molecular Weight	275.77 g/mol
Synonyms	3-Hydroxy-1-(diphenylmethyl)azetidine hydrochloride; 1-(Benzhydryl)-3-hydroxyazetidine hydrochloride; Azetidin-3-ol, 1-(diphenylmethyl)-, hydrochloride; 1-(Diphenylmethyl)azetidin-3-ol hydrochloride; Benzhydryl 3-hydroxyazetidine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Diphenylmethyl)-3-Hydroxyazetidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent determination, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.