Description

n-(1-Naphthalenesulfonyl)-L-Phenylalanine is a specialized chiral sulfonamide derivative that serves as a key synthetic intermediate and research chemical. Its molecular structure, combining a naphthalenesulfonyl group with the L-phenylalanine backbone, makes it valuable for constructing complex molecules with specific stereochemistry. This compound is primarily utilized by research institutions and pharmaceutical developers in the synthesis of peptide mimetics, enzyme inhibitors, and as a building block for novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial chiral building block in the research and development of new therapeutic agents, particularly for protease inhibitors and other enzyme-targeted drugs.
• Peptidomimetic Synthesis: Used to introduce the naphthalenesulfonyl (Ns) protecting group and the phenylalanine side chain in the design of peptide analogs with enhanced stability and bioavailability.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to investigate reaction mechanisms and enzyme specificity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or reagent in stereoselective chemical reactions to produce enantiomerically pure compounds.
• Chemical Biology Probes: Utilized in the development of molecular probes for labeling or modulating protein function in cellular studies.

Basic Information

Product Name	n-(1-Naphthalenesulfonyl)-L-Phenylalanine
CAS No.	90291-46-6
Molecular Formula	C19H17NO4S
Molecular Weight	355.41 g/mol
Synonyms	L-Phenylalanine, N-(1-naphthalenesulfonyl)-; N-(1-Naphthylsulfonyl)-L-phenylalanine; N-1-Naphthalenesulfonyl-L-phenylalanine; Ns-Phe-OH; 1-Naphthalenesulfonamide, N-[(1S)-1-carboxy-2-phenylethyl]-; (S)-2-((Naphthalene-1-sulfonamido)methyl)-3-phenylpropanoic acid; N-[(1S)-2-Phenyl-1-(sulfooxycarbonyl)ethyl]-1-naphthalenesulfonamide
EINECS	Contact for details

Quality Control

Our n-(1-Naphthalenesulfonyl)-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical development. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.