Description

Colominic Acid is a linear homopolymer of α-(2→8)-linked N-acetylneuraminic acid (sialic acid), a polysaccharide of significant biological and commercial interest. Its unique structure makes it a critical material for research in microbiology, immunology, and glycobiology. This product is essential for manufacturers and research institutions developing vaccines, diagnostic reagents, and studying bacterial pathogenesis and cell surface interactions.

Application

• Vaccine Adjuvant & Conjugate Development: Used as a carrier or immunostimulant in the formulation of next-generation bacterial vaccines, particularly against Neisseria meningitidis Group B and Escherichia coli K1.
• Biomedical Research Reagent: Serves as a standard or substrate in enzymatic assays (sialidases), receptor-ligand binding studies, and investigations into neural cell adhesion and development.
• Diagnostic Kit Component: Employed in the production of immunoassays and lateral flow tests for the detection of specific antibodies or bacterial capsular antigens.
• Glycoconjugate Synthesis: Acts as a starting material or intermediate for the chemical and enzymatic synthesis of more complex glycans and neoglycoconjugates.
• Cell Culture & Neuroscience Studies: Used to modulate cell growth, differentiation, and to study the role of polysialic acid in neural plasticity and memory.
• Pharmaceutical Excipient: Explored for its potential in drug delivery systems due to its biocompatibility and specific biological interactions.

Basic Information

Product Name	Colominic Acid
CAS No.	9013-15-4
Molecular Formula	(C11H17NO8)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(α-2,8-N-acetylneuraminic acid); Polysialic Acid; PolySia; PSA; α-2,8-Linked NANA Polymer; Homopolymer of N-Acetylneuraminic Acid; Meningococcal Group B Polysaccharide; E. coli K1 Capsular Polysaccharide; Colominic Acid Sodium Salt (common form).
EINECS	Contact for details

Quality Control

Our Colominic Acid is produced and tested under a strict quality management system. Each batch is characterized for critical parameters including molecular weight distribution, sialic acid content, and purity to ensure consistency for research and development applications. A comprehensive Certificate of Analysis (COA) detailing specifications and test results (e.g., by HPAEC-PAD, NMR, UV-Vis) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or fibrous solid
Identification (IR/NMR)	Conforms to structure
Assay (Sialic Acid Content)	≥ 95% (by colorimetric or chromatographic methods)
Molecular Weight (Average)	Specified range available (e.g., 10-50 kDa)
Protein Content	< 1% (w/w)
Nucleic Acid Content	< 0.5% (w/w)
Endotoxin Level	< 10 EU/mg (for research-grade applications)
Water Content (KF)	< 5.0%
Solubility	Soluble in water and saline solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.