Description

3,3-Pentamethylenediazirin is a specialized diazirine-based photoaffinity labeling reagent. This compound matters for its ability to form highly reactive carbene intermediates upon photolysis, enabling the covalent cross-linking and study of biomolecular interactions. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and chemical synthesis sectors for applications in drug discovery, proteomics, and materials science.

Application

• Photoaffinity Labeling (PAL): A critical tool in chemical biology for mapping protein-ligand binding sites and identifying unknown biological targets.
• Proteomics Research: Used to study protein-protein interactions and protein structure-function relationships through covalent cross-linking.
• Drug Discovery: Facilitates the development of new therapeutic agents by enabling the study of drug-target engagement and off-target effects.
• Bioconjugation: Serves as a photochemical handle for attaching probes, tags, or other molecules to biomolecules under mild conditions.
• Materials Science: Employed in surface modification and the creation of photo-crosslinkable polymers and advanced materials.
• Organic Synthesis Intermediate: Acts as a precursor for synthesizing more complex molecules containing the diazirine functional group.

Basic Information

Product Name	3,3-Pentamethylenediazirin
CAS No.	930-82-5
Molecular Formula	C7H12N2
Molecular Weight	124.18 g/mol
Synonyms	3,3-Pentamethylene-1-pyrazoline; 3,3-Pentamethylenediaziridine; 1-Pyrazoline, 3,3-pentamethylene-; Diaziridine, 3,3-pentamethylene-; 3,3-(Pentane-1,5-diyl)diaziridine; 3,3-Pentamethylene-δ1-pyrazoline; 3,3-Pentamethylenediazirine (preferred IUPAC-like name); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our 3,3-Pentamethylenediazirin is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. We prioritize high purity and stability, with comprehensive analytical testing including HPLC, NMR, and GC-MS. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request for every lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended temperatures between 2°C and 8°C (refrigerated) or as specified on the label. This product is light-sensitive (store away from light). Keep container tightly sealed under an inert atmosphere if specified for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.