Description

1-[3-(Trifluoromethyl)Benzyl]Piperidine-3-Carboxylic Acid is a high-value, fluorinated piperidine derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both a trifluoromethylbenzyl group and a carboxylic acid moiety, makes it an essential intermediate for the development of novel bioactive compounds. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of new drug candidates, particularly for central nervous system (CNS) targets, enzyme inhibitors, and receptor modulators.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can improve metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Chemical Biology Probe Synthesis: Employed to create molecular probes for studying biological pathways and protein functions.
• Material Science Research: Potential monomer or additive for creating specialty polymers with unique surface properties.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	1-[3-(Trifluoromethyl)Benzyl]Piperidine-3-Carboxylic Acid
CAS No.	896045-95-7
Molecular Formula	C14H16F3NO2
Molecular Weight	287.28 g/mol
Synonyms	3-[[[3-(Trifluoromethyl)phenyl]methyl]-3-piperidinecarboxylic acid; 1-[(3-Trifluoromethyl)benzyl]piperidine-3-carboxylic acid; Piperidine-3-carboxylic acid, 1-[[3-(trifluoromethyl)phenyl]methyl]-; α-(3-Trifluoromethylbenzyl)nipecotic acid; 1-(3-Trifluoromethylbenzyl)-3-piperidinecarboxylic acid; Nipecotic acid, α-(3-trifluoromethylbenzyl)-; 896045-95-7; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of 1-[3-(Trifluoromethyl)Benzyl]Piperidine-3-Carboxylic Acid adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as identity, assay, and impurity profiles. We support our clients' regulatory needs and can provide material suitable for use under cGMP guidelines for non-clinical development stages upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.