Description

Ethyl 6-Bromo-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its brominated naphthyridine core structure. This compound is of critical importance for its role as a versatile building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs targeting various disease pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those with a 1,8-naphthyridine scaffold.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Development: Serves as a core building block for the creation of potent and selective kinase inhibitors, a major class of targeted cancer therapies.
• Chemical Synthesis: Utilized in organic synthesis for constructing complex heterocyclic systems due to its reactive bromo and ester functional groups.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the pharmaceutical industry.
• Academic Research: Employed in university and institutional labs for fundamental studies in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Product Name	Ethyl 6-Bromo-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate
CAS No.	894851-71-9
Molecular Formula	C11H9BrN2O3
Molecular Weight	297.11 g/mol
Synonyms	6-Bromo-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid ethyl ester; Ethyl 6-bromo-1,8-naphthyridin-2(1H)-one-3-carboxylate; 6-Bromo-1,2-dihydro-2-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester; 3-Carbethoxy-6-bromo-1,8-naphthyridin-2(1H)-one; 894851-71-9; 6-Bromo-2-oxo-1,2-dihydro[1,8]naphthyridine-3-carboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 6-Bromo-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. All products undergo rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.