Description

[1,1'-Biphenyl]-3-Carboxylic Acid, 4-Hydroxy-3',5'-Bis(Trifluoromethyl)- is a high-value, multi-functional biphenyl derivative characterized by its carboxylic acid and phenolic hydroxyl groups, flanked by electron-withdrawing trifluoromethyl substituents. This unique structure makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for synthesizing complex organic molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing new active compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Serves as a core scaffold for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Used in organometallic chemistry to create sophisticated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and polymers due to its rigid biphenyl core and fluorine content.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags, enzyme inhibitors, and other molecular probes in biochemical research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring complex, fluorinated aromatic structures.

Basic Information

Item	Details
Product Name	[1,1'-Biphenyl]-3-Carboxylic Acid, 4-Hydroxy-3',5'-Bis(Trifluoromethyl)-
CAS No.	893638-28-3
Molecular Formula	C₁₆H₉F₆O₃
Molecular Weight	378.24 g/mol
Synonyms	4-Hydroxy-3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-3-carboxylic acid; 3'-Carboxy-4'-hydroxy-3,5-bis(trifluoromethyl)biphenyl; 4'-Hydroxy-3,5-bis(trifluoromethyl)biphenyl-3'-carboxylic acid; 3-Carboxy-4-hydroxy-3',5'-bis(trifluoromethyl)biphenyl; Biphenyl-3-carboxylic acid, 4-hydroxy-3',5'-bis(trifluoromethyl)-; 893638-28-3
EINECS	Contact for details

Quality Control

Our production of [1,1'-Biphenyl]-3-Carboxylic Acid, 4-Hydroxy-3',5'-Bis(Trifluoromethyl)- adheres to stringent cGMP and ISO 9001 quality management principles. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.