Description

tert-Butyl 4-Quinolin-2-Ylpiperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate and building block of significant importance in modern organic synthesis. This compound matters for its critical role as a key precursor in the development of active pharmaceutical ingredients (APIs), particularly in therapeutic areas targeting the central nervous system and oncology. Pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) need this high-quality intermediate to ensure the reliability and scalability of their synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of complex drug candidates, particularly those with quinoline and piperazine pharmacophores.
• API Development: Used in research and development for novel Active Pharmaceutical Ingredients targeting neurological disorders and cancer.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to construct more complex molecular architectures for specialized applications.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	tert-Butyl 4-Quinolin-2-Ylpiperazine-1-Carboxylate
CAS No.	890709-17-8
Molecular Formula	C18H23N3O2
Molecular Weight	313.40 g/mol
Synonyms	tert-Butyl 4-(quinolin-2-yl)piperazine-1-carboxylate; 1-Boc-4-(2-quinolyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(2-quinolyl)piperazine; 4-(Quinolin-2-yl)piperazine-1-carboxylic acid tert-butyl ester; 2-(1-Boc-piperazin-4-yl)quinoline; BOC-2-Quinolylpiperazine; 890709-17-8; tert-Butyl 4-(2-quinolyl)piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Quinolin-2-Ylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can align with cGMP guidelines for pharmaceutical applications, ensuring supply chain integrity for critical R&D and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider inert atmosphere conditions to maximize stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.