Description

n-Piperidin-4-Yl-2-(Trifluoromethyl)-1,6-Naphthyridin-5-Amine is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 890302-20-2. This compound is valued for its complex heterocyclic structure, which serves as a critical building block in modern medicinal chemistry. It is primarily sought by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of investigational new drugs and targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Oncology Drug Development: Employed in the creation of kinase inhibitors and other targeted cancer treatments due to its naphthyridine scaffold.
• CNS-Active Compound Synthesis: Serves as a building block for potential neuropharmaceuticals, leveraging the piperidine moiety.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche APIs.

Basic Information

Product Name	n-Piperidin-4-Yl-2-(Trifluoromethyl)-1,6-Naphthyridin-5-Amine
CAS No.	890302-20-2
Molecular Formula	C15H15F3N4
Molecular Weight	308.31 g/mol
Synonyms	2-(Trifluoromethyl)-1,6-naphthyridin-5-amine, 4-piperidinyl-; 4-[(2-Trifluoromethyl-1,6-naphthyridin-5-yl)amino]piperidine; 5-Piperidin-4-ylamino-2-trifluoromethyl-1,6-naphthyridine; 890302-20-2; 4-[(2-(Trifluoromethyl)-1,6-naphthyridin-5-yl)amino]piperidine; 1,6-Naphthyridin-5-amine, 4-(4-piperidinylamino)-2-(trifluoromethyl)-; 5-Amino-2-trifluoromethyl-1,6-naphthyridine-4-piperidine
EINECS	Contact for details

Quality Control

Our n-Piperidin-4-Yl-2-(Trifluoromethyl)-1,6-Naphthyridin-5-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide comprehensive Certificates of Analysis (COA) to ensure traceability and compliance with your research or cGMP guidelines for early-phase development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.