Description

5-Chloro-2-(trifluoromethyl)-1,6-naphthyridine is a high-value, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a naphthyridine scaffold with chloro and trifluoromethyl substituents, enabling precise modulation of electronic and steric properties in target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, where it serves as a critical intermediate in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Active Ingredient Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, leveraging the biological activity of the naphthyridine core.
• Material Science Research: Serves as a building block for developing advanced organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Biology Probe Development: Utilized in creating molecular probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	5-Chloro-2-(trifluoromethyl)-1,6-naphthyridine
CAS No.	890301-88-9
Molecular Formula	C9H4ClF3N2
Molecular Weight	232.59 g/mol
Synonyms	5-Chloro-2-(trifluoromethyl)-1,6-naphthyridine; 1,6-Naphthyridine, 5-chloro-2-(trifluoromethyl)-; 2-(Trifluoromethyl)-5-chloro-1,6-naphthyridine; 5-Chloro-2-trifluoromethyl-1,6-naphthyridine; 890301-88-9; 5-Chloro-2-(trifluoromethyl)[1,6]naphthyridine
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(trifluoromethyl)-1,6-naphthyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from techniques such as HPLC, NMR, and GC-MS. Our quality commitment ensures the material meets the stringent requirements for research and pre-clinical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.