Description

(4-Oxo-6-Piperazin-1-Yl-4H-Quinazolin-3-Yl)-Acetic Acid is a high-purity, advanced pharmaceutical intermediate with a quinazolinone core structure. This compound is valued for its role as a critical building block in the research and development of novel therapeutic agents, particularly kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers targeting oncology and other disease areas. Its precise chemical architecture enables the synthesis of complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors for oncology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• Biochemical Tool Compound: Serves as a reference standard or a starting point for developing novel biochemical probes.
• API Development: Employed in the process development and scale-up of new active pharmaceutical ingredients (APIs).
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental research in drug discovery pathways.

Basic Information

Product Name	(4-Oxo-6-Piperazin-1-Yl-4H-Quinazolin-3-Yl)-Acetic Acid
CAS No.	889958-08-1
Molecular Formula	C₁₄H₁₆N₄O₃
Molecular Weight	288.30 g/mol
Synonyms	6-(Piperazin-1-yl)-4-oxo-1,4-dihydroquinazoline-3-acetic acid; 2-[6-(Piperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]acetic acid; (4-Oxo-6-piperazin-1-yl-1,4-dihydroquinazolin-3-yl)acetic acid; Quinazolin-3-yl-acetic acid derivative; 889958-08-1; UNII-7QK6SQA9VY
EINECS	Contact for details

Quality Control

Our (4-Oxo-6-Piperazin-1-Yl-4H-Quinazolin-3-Yl)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.