Description

(S)-1-n-Fmoc-2-Methyl-Piperazine is a high-purity, chiral piperazine derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in modern pharmaceutical research and development, particularly for the synthesis of complex, biologically active molecules. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel drug candidates, especially in peptide mimetics and small molecule libraries.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Peptidomimetic Chemistry: Serves as a constrained, chiral scaffold to replace peptide bonds, enhancing metabolic stability and bioavailability in drug design.
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid analog for the introduction of the (S)-2-methylpiperazine moiety into peptide chains under standard Fmoc chemistry conditions.
• Library Synthesis for Drug Discovery: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for screening against novel biological targets.
• Asymmetric Synthesis: Acts as a chiral auxiliary or building block in catalytic asymmetric reactions to induce stereoselectivity.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme mechanisms and protein-protein interactions.

Basic Information

Product Name	(S)-1-n-Fmoc-2-Methyl-Piperazine
CAS No.	888972-50-7
Molecular Formula	C21H24N2O2
Molecular Weight	336.43 g/mol
Synonyms	(S)-1-((9H-Fluoren-9-yl)methoxy)carbonyl-2-methylpiperazine; (S)-N-Fmoc-2-methylpiperazine; (S)-2-Methyl-1-(9-fluorenylmethoxycarbonyl)piperazine; (S)-1-Fmoc-2-methylpiperazine; (S)-N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methylpiperazine; (S)-2-Methylpiperazine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester; Fmoc-(S)-2-methylpiperazine; (S)-2-Methyl-1-piperazinecarboxylic acid 9-fluorenylmethyl ester
EINECS	Contact for details

Quality Control

Our (S)-1-n-Fmoc-2-Methyl-Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral assay, and identity confirmation is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.