Description

1'-(tert-Butoxycarbonyl)Spiro[Indoline-3,4'-Piperidine]-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) therapeutics, oncology treatments, and other innovative small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: Used in the research and synthesis of potential inhibitors for various protease enzymes.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological pathways and protein function.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for methodological development and novel synthetic route exploration.

Basic Information

Product Name	1'-(tert-Butoxycarbonyl)Spiro[Indoline-3,4'-Piperidine]-5-Carboxylic Acid
CAS No.	888222-12-6
Molecular Formula	C18H24N2O4
Molecular Weight	332.40 g/mol
Synonyms	Boc-Spiro[Indoline-3,4'-Piperidine]-5-Carboxylic Acid; 5-Carboxy-1'-N-Boc-spiro[indoline-3,4'-piperidine]; 1'-Boc-spiro[indoline-3,4'-piperidine]-5-carboxylic acid; tert-Butyl 5-carboxyspiro[indoline-3,4'-piperidine]-1'-carboxylate; Spiro[indoline-3,4'-piperidine]-5-carboxylic acid, 1'-(1,1-dimethylethyl) ester; 888222-12-6; 1'-(tert-Butoxycarbonyl)-1,3-dihydrospiro[indene-2,4'-piperidine]-5-carboxylic acid (related structure).
EINECS	Contact for details

Quality Control

Our 1'-(tert-Butoxycarbonyl)Spiro[Indoline-3,4'-Piperidine]-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.