Description

Bis[Di-(tert-Butyl)(4-Trifluoromethylphenyl)Phosphine]Palladium(II) Chloride is a highly specialized, air-stable palladium catalyst featuring bulky, electron-rich phosphine ligands. This compound is engineered to provide exceptional catalytic activity and selectivity in demanding cross-coupling reactions, crucial for constructing complex molecular architectures. It is an indispensable tool for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where precision and reproducibility are paramount. The product is supplied under an inert atmosphere to ensure optimal performance and shelf life.

Application

This catalyst is designed for high-performance applications in organic synthesis, particularly where standard catalysts fail. Key uses include:

• Pharmaceutical Intermediate Synthesis: Enabling key carbon-carbon and carbon-heteroatom bond formations in API development.
• Agrochemical Research: Facilitating the synthesis of novel active ingredients with complex structures.
• Cross-Coupling Reactions: Specialized for Buchwald-Hartwig amination, Suzuki-Miyaura, and Negishi couplings under mild conditions.
• Advanced Material Development: Used in the synthesis of organic semiconductors, ligands, and conductive polymers.
• Process Chemistry & Scale-Up: Valued for its robustness and consistent performance in pilot and manufacturing-scale reactions.
• Academic & Industrial R&D: A critical reagent for methodological development and exploring new chemical spaces.

Basic Information

Product Name	Bis[Di-(tert-Butyl)(4-Trifluoromethylphenyl)Phosphine]Palladium(II) Chloride
CAS No.	887919-36-0
Molecular Formula	C38H50ClF6P2Pd
Molecular Weight	849.58 g/mol
Synonyms	Bis(di-tert-butyl(4-(trifluoromethyl)phenyl)phosphine)palladium(II) chloride; Pd(dtbpf)Cl2; Palladium(II) chloride bis(di-tert-butyl(4-trifluoromethylphenyl)phosphine); [Pd(PCy2(4-CF3-C6H4))2Cl2]; Di-tert-butyl(4-trifluoromethylphenyl)phosphine palladium(II) chloride complex; (DtBPF)PdCl2; Palladium catalyst 887919-36-0; Pd(DTBPF)Cl2
EINECS	Contact for details

Quality Control

Our production of Bis[Di-(tert-Butyl)(4-Trifluoromethylphenyl)Phosphine]Palladium(II) Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and high catalytic performance. Every lot is characterized using advanced analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and metal content is provided with each shipment. We support compliance with relevant GMP and ISO 9001 standards for research and development use.

Storage

Preserve in the original tightly closed container under an inert atmosphere (argon or nitrogen). Store in a cool, dry place, protected from light. Recommended long-term storage temperature is 2-8°C. The material is easily oxidized and moisture-sensitive; allow the sealed container to reach room temperature before opening to prevent condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Palladium (Pd) Content	12.0 - 13.0 %
Chloride (Cl) Content	8.0 - 8.5 %
Solubility	Soluble in common organic solvents (DCM, THF, Toluene)
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.