Description

3-Trifluoromethoxy-Benzyl-Hydrazine is a specialized aromatic hydrazine derivative, a high-value building block prized for its unique trifluoromethoxy-substituted benzyl moiety. This compound matters for its role in facilitating the synthesis of complex heterocycles and active pharmaceutical ingredients (APIs), where it introduces key hydrazine and aromatic functionalities. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for the construction of hydrazone linkages and heterocyclic cores like pyrazoles and triazoles.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethoxy group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chelating ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and material science.
• Functional Material Research: Employed in the synthesis of organic electronic materials, liquid crystals, and polymers where specific aromatic and fluorine-containing units are required.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes and tags for studying biological processes and enzyme inhibition.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the fine chemical industry.

Basic Information

Product Name	3-Trifluoromethoxy-Benzyl-Hydrazine
CAS No.	887595-84-8
Molecular Formula	C8H9F3N2O
Molecular Weight	206.17 g/mol
Synonyms	1-[(3-Trifluoromethoxy)phenyl]methylhydrazine; (3-(Trifluoromethoxy)phenyl)methanamine, N-amino-; α-Hydrazino-3-(trifluoromethoxy)toluene; 3-(Trifluoromethoxy)benzylhydrazine; m-Trifluoromethoxybenzylhydrazine; Hydrazine, [(3-trifluoromethoxyphenyl)methyl]-; 887595-84-8
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethoxy-Benzyl-Hydrazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed batch-specific data are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). Keep the container in a cool, dry, and well-ventilated place separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.