Description

3,5-Difluoro-Benzyl-Hydrazine is a specialized aromatic hydrazine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the benzyl ring, which can significantly alter the electronic properties, metabolic stability, and binding affinity of final target molecules. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing novel heterocycles and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the difluoro-benzyl moiety enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for metal-catalyzed cross-coupling reactions and asymmetric synthesis.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of advanced polymers and liquid crystals with specific optical or electronic properties.
• Fluorinated Compound Library: A valuable scaffold for medicinal chemistry to build diverse compound libraries for high-throughput screening (HTS) in drug discovery.

Basic Information

Product Name	3,5-Difluoro-Benzyl-Hydrazine
CAS No.	887595-39-3
Molecular Formula	C7H8F2N2
Molecular Weight	158.15 g/mol
Synonyms	(3,5-Difluorophenyl)methanamine, hydrazone; 1-(3,5-Difluorobenzyl)hydrazine; 3,5-Difluorobenzylhydrazine; Hydrazine, (3,5-difluorobenzyl)-; Benzylhydrazine, 3,5-difluoro-; (3,5-Difluorobenzyl)hydrazine; α-Hydrazino-3,5-difluorotoluene
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-Benzyl-Hydrazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques like HPLC, GC, and NMR. We adhere to relevant industry standards and can support development under cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to minimize degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.