Description

Methyl 6,8-Difluoro-4-Hydroxyquinoline-2-Carboxylate is a high-purity fluorinated quinoline derivative serving as a critical advanced pharmaceutical intermediate. This compound is valued for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing next-generation fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel antibacterial and anticancer agents, leveraging the bioactivity of the quinoline core and fluorine substituents.
• Agrochemical Research: Used in developing new fluorinated pesticides and herbicides, where the difluoro-hydroxyquinoline structure can enhance biological activity and environmental stability.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of libraries of compounds for high-throughput screening in drug discovery.
• Material Science: Investigated as a potential component in the synthesis of organic semiconductors or fluorescent materials due to its conjugated quinoline system.

Basic Information

Product Name	Methyl 6,8-Difluoro-4-Hydroxyquinoline-2-Carboxylate
CAS No.	887589-28-8
Molecular Formula	C11H7F2NO3
Molecular Weight	239.18 g/mol
Synonyms	6,8-Difluoro-4-hydroxyquinoline-2-carboxylic acid methyl ester; Methyl 6,8-difluoro-4-oxo-1,4-dihydroquinoline-2-carboxylate; 2-Quinolinecarboxylic acid, 6,8-difluoro-4-hydroxy-, methyl ester; 4-Hydroxy-6,8-difluoroquinoline-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 6,8-Difluoro-4-Hydroxyquinoline-2-Carboxylate adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.