Description

n-Nitrosoanatabine is a nitrosated derivative of the tobacco alkaloid anatabine. This compound is of significant interest in analytical chemistry and toxicological research, particularly for the study of tobacco-specific nitrosamines (TSNAs) and their formation pathways. It serves as a critical reference standard and research chemical for laboratories in the pharmaceutical, analytical, and regulatory sectors focused on product safety and chemical carcinogenesis.

Application

• Analytical Reference Standard: Primary use as a high-purity certified reference material (CRM) for the calibration of analytical instruments like HPLC, GC-MS, and LC-MS/MS.
• Toxicology Research: Essential for in-vitro and in-vivo studies investigating the metabolism, bioavailability, and carcinogenic potential of tobacco-specific nitrosamines.
• Method Development & Validation: Used by testing laboratories to develop, optimize, and validate analytical methods for the detection and quantification of nitrosamine impurities.
• Pharmaceutical Impurity Profiling: Employed in the identification and control of potentially genotoxic nitrosamine impurities (PGIs) in active pharmaceutical ingredients (APIs) and drug products, aligning with ICH M7 and regulatory guidelines.
• Food & Agricultural Safety: Research into nitrosamine formation in food products, tobacco, and agricultural commodities to assess exposure risks.
• Academic & Institutional Research: Serves as a key reagent for universities and research institutes studying organic reaction mechanisms, especially nitrosation chemistry.

Basic Information

Product Name	n-Nitrosoanatabine
CAS No.	887407-16-1
Molecular Formula	C10H11N3O
Molecular Weight	189.21 g/mol
Synonyms	N-Nitrosoanatabine; Anatabine, N-nitroso-; 3-[(2S)-1-Methyl-2-pyrrolidinyl]-2-pyridinyl]nitrosoamine; N-Nitrosoanatabine (NNAT); TSNA Research Standard; Nitrosated Anatabine; N-Nitroso derivative of Anatabine
EINECS	Contact for details

Quality Control

Every batch of n-Nitrosoanatabine is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support its use as a research and reference material. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity confirmation (IR, NMR), and impurity profiles (HPLC) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term stability, consider storage at 2-8°C. The compound is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.