Description

8-Quinolinecarboxylic Acid, 4-Hydroxy-2-(Trifluoromethyl)-, Methyl Ester is a high-purity, fluorinated quinoline derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the unique combination of the quinoline scaffold and the trifluoromethyl group, which is highly sought after for modulating the physicochemical properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in areas targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the CF3 group enhances bioavailability and metabolic stability.
• Material Science Research: Serves as a precursor for developing organic semiconductors, fluorescent dyes, and metal-chelating ligands due to its conjugated quinoline structure.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services for clients in regulated industries.

Basic Information

Product Name	8-Quinolinecarboxylic Acid, 4-Hydroxy-2-(Trifluoromethyl)-, Methyl Ester
CAS No.	887351-07-7
Molecular Formula	C12H8F3NO3
Molecular Weight	271.19 g/mol
Synonyms	Methyl 4-hydroxy-2-(trifluoromethyl)quinoline-8-carboxylate; 4-Hydroxy-2-(trifluoromethyl)quinoline-8-carboxylic acid methyl ester; 2-Trifluoromethyl-4-hydroxy-quinoline-8-carboxylic acid methyl ester; 8-Quinolinecarboxylic acid, 4-hydroxy-2-(trifluoromethyl)-, methyl ester; Quinoline-8-carboxylic acid, 4-hydroxy-2-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Every batch of 8-Quinolinecarboxylic Acid, 4-Hydroxy-2-(Trifluoromethyl)-, Methyl Ester is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency meet the high standards required for advanced R&D and scale-up. Certificates of Analysis (COA) with full traceability are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from moisture and direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.