Description

1-[(tert-Butyl)Oxycarbonyl]-3-Pyridin-3-Ylmethylpiperidine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core with both Boc-protected amine and carboxylic acid functionalities. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with precise stereochemistry. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly for neurological and oncological targets.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Protease Inhibitor Research: Serves as a core scaffold for developing inhibitors of specific proteolytic enzymes.
• Ligand Synthesis for Receptor Studies: Used to create specialized ligands for pharmacological characterization of G-protein coupled receptors (GPCRs).
• Peptidomimetic Chemistry: Integral component in the design and construction of peptidomimetics to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Employed in the development of tool compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	1-[(tert-Butyl)Oxycarbonyl]-3-Pyridin-3-Ylmethylpiperidine-3-Carboxylic Acid
CAS No.	887344-18-5
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	3-[(3-Pyridinylmethyl)-3-piperidinecarboxylic acid, 1-(1,1-dimethylethyl) ester; 1-Boc-3-(pyridin-3-ylmethyl)piperidine-3-carboxylic acid; tert-Butyl 3-(pyridin-3-ylmethyl)-3-carboxypiperidine-1-carboxylate; 1-N-Boc-3-(3-pyridylmethyl)nipecotic acid; 3-Carboxy-1-Boc-3-(3-pyridinylmethyl)piperidine; 887344-18-5; 1-(tert-Butoxycarbonyl)-3-(pyridin-3-ylmethyl)piperidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-[(tert-Butyl)Oxycarbonyl]-3-Pyridin-3-Ylmethylpiperidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment. We support development from research to commercial scale with consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.