Description

1,3-Dihydro-3,3-Dimethyl-1-(Trifluoromethyl)-1,2-Benziodoxole, Tognis Reagent is a highly specialized hypervalent iodine(III) reagent, recognized for its powerful trifluoromethylation capabilities. This compound matters because it provides a stable, user-friendly, and highly selective source of the CF3 group, a critical transformation in modern synthetic chemistry. It is essential for R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors who require efficient methods for introducing fluorine-containing motifs to enhance the properties of target molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the late-stage trifluoromethylation of complex drug candidates and bioactive molecules.
• Agrochemical Development: Used to incorporate the CF3 group into novel herbicides, fungicides, and insecticides to improve metabolic stability and activity.
• Material Science Research: Enables the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers with tailored electronic and surface properties.
• Academic & Industrial R&D: A staple reagent in method development for new C–CF3 and heteroatom–CF3 bond-forming reactions.
• Radiopharmaceutical Chemistry: Potential utility in the synthesis of fluorine-18 labeled precursors via related chemistries.
• Fine Chemical Production: Employed in the scalable manufacture of fluorinated building blocks and specialty chemicals.

Basic Information

Product Name	1,3-Dihydro-3,3-Dimethyl-1-(Trifluoromethyl)-1,2-Benziodoxole, Tognis Reagent
CAS No.	887144-97-0
Molecular Formula	C9H8F3IO
Molecular Weight	316.06 g/mol
Synonyms	Togni Reagent I; 3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole; 1-Trifluoromethyl-1,2-benziodoxol-3(1H)-one; (Trifluoromethyl)benziodoxole; Hypervalent Iodine Trifluoromethylation Reagent; Togni's Reagent; CF3-Benziodoxole
EINECS	Contact for details

Quality Control

Every batch of our Tognis Reagent is manufactured and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to support cGMP-compliant workflows for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. This material is light-sensitive and easily oxidized; prolonged exposure to air, moisture, or light should be avoided to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.