Description

2-Bromo-2',3'-Difluoroacetophenone, 2-Bromo-1-(2,3-Difluorophenyl)Ethan-1-One is a high-value, multi-functional organic building block characterized by its reactive bromo and carbonyl groups on a difluorinated aromatic ring. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is a key strategy for modulating bioactivity and metabolic stability. It is essential for R&D chemists and process development scientists working on novel active ingredients, advanced materials, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, including kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the difluorophenyl moiety enhances lipophilicity and target binding.
• Material Science Research: Serves as a building block for creating novel fluorinated polymers, liquid crystals, and organic electronic materials with tailored properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl structures.
• Nucleophilic Substitution: The α-bromo ketone functionality is reactive towards various nucleophiles, enabling the introduction of diverse side chains for library synthesis in medicinal chemistry.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling in related API manufacturing.

Basic Information

Item	Details
Product Name	2-Bromo-2',3'-Difluoroacetophenone, 2-Bromo-1-(2,3-Difluorophenyl)Ethan-1-One
CAS No.	886762-77-2
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	2-Bromo-1-(2,3-difluorophenyl)ethanone; 2-Bromo-2',3'-difluoroacetophenone; α-Bromo-2,3-difluoroacetophenone; 1-(2,3-Difluorophenyl)-2-bromoethanone; 2-Bromo-2,3-difluoroacetophenone; Ethanone, 2-bromo-1-(2,3-difluorophenyl)-; 886762-77-2
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-2',3'-Difluoroacetophenone undergoes rigorous quality testing to ensure compliance with stringent industry standards. Our quality management system is designed to guarantee high purity, batch-to-batch consistency, and reliable supply for critical R&D and production processes. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.