Description

2-Fluoro-5-Methylbenzamide is a high-purity fluorinated aromatic amide building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the fluorine atom and amide group are crucial for modulating biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific structural motifs into novel molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the fluorine substituent enhances bioavailability and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and liquid crystals, where fluorinated aromatic units impart unique thermal and optical properties.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic and Industrial R&D: Used in research laboratories for method development and exploring new chemical reactions involving fluorinated arenes.

Basic Information

Product Name	2-Fluoro-5-Methylbenzamide
CAS No.	886500-04-5
Molecular Formula	C8H8FNO
Molecular Weight	153.15 g/mol
Synonyms	2-Fluoro-5-methylbenzamide; 5-Methyl-2-fluorobenzamide; Benzamide, 2-fluoro-5-methyl-; 886500-04-5; 2-Fluoro-5-methyl-benzoic acid amide; 2-Fluoro-5-methylbenzenecarboxamide; 5-Methyl-2-fluorobenzoic acid amide
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Methylbenzamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive quality assurance, with products typically meeting a purity specification of ≥97% (by HPLC). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. Our quality commitment aligns with the standards required for pharmaceutical and agrochemical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.