Description

3-Chloro-5-(Trifluoromethyl)Phenylacetic Acid is a high-value fluorinated aromatic building block essential for advanced chemical synthesis. This compound matters for its unique trifluoromethyl and chloro substituents, which impart desirable properties like metabolic stability and lipophilicity to target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of new active ingredients, including potential herbicides, fungicides, and pharmaceutical intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly where enhanced bioavailability and metabolic resistance are required.
• Agrochemical Synthesis: Serves as a critical precursor in the manufacture of advanced herbicides and fungicides, leveraging the biological activity of the trifluoromethyl group.
• Liquid Crystal & OLED Materials: Used in the synthesis of specialty chemicals for electronic applications, where its aromatic and fluorinated structure contributes to desired electronic properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and amide formations to introduce a substituted phenylacetic acid moiety into complex molecular architectures.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and material science research in academic and industrial laboratories.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Phenylacetic Acid
CAS No.	886496-99-7
Molecular Formula	C9H6ClF3O2
Molecular Weight	238.59 g/mol
Synonyms	[3-Chloro-5-(trifluoromethyl)phenyl]acetic acid; 2-[3-Chloro-5-(trifluoromethyl)phenyl]acetic acid; 3-Chloro-α,α,α-trifluoro-m-toluic acid, acetic acid derivative; (3-Chloro-5-trifluoromethylphenyl)acetic acid; m-Chloro-α,α,α-trifluoromethylphenylacetic acid; 886496-99-7; 3-Chloro-5-trifluoromethylphenylacetic acid
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethyl)Phenylacetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.