Description

2-Chloro-4-(trifluoromethyl)-5,6,7,8-tetrahydroquinazoline (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated and fluorinated heterocyclic structure. This compound is of significant value for its role as a key synthetic building block in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors engaged in drug discovery, process development, and scale-up synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Material Science: Acts as a monomer or functional additive in the research of specialty polymers and advanced organic electronic materials.
• Chemical Synthesis: Employed in academic and industrial R&D for constructing complex heterocyclic frameworks and exploring novel organic reactions.
• Ligand & Catalyst Development: Utilized as a scaffold for creating novel ligands in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Chloro-4-(trifluoromethyl)-5,6,7,8-tetrahydroquinazoline (Saltdata: Free)
CAS No.	886494-00-4
Molecular Formula	C9H8ClF3N2
Molecular Weight	236.62 g/mol
Synonyms	2-Chloro-4-(trifluoromethyl)-5,6,7,8-tetrahydroquinazoline; 5,6,7,8-Tetrahydro-2-chloro-4-(trifluoromethyl)quinazoline; 886494-00-4; 2-Chloro-4-trifluoromethyl-5,6,7,8-tetrahydroquinazoline; Tetrahydro-2-chloro-4-(trifluoromethyl)quinazoline
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(trifluoromethyl)-5,6,7,8-tetrahydroquinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.