Description

1-Boc-5-Fluoro-3-Indazole-Carboxylic Acid is a high-purity, protected indazole derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within therapeutic areas requiring fluorinated heterocycles.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable carboxylic acid and protected amine functionalities.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for creating peptide-like molecules with enhanced metabolic stability and bioavailability.
• Agrochemical Development: Employed in the research and synthesis of new generation herbicides and pesticides that incorporate fluorinated heterocyclic motifs.
• Chemical Biology Probes: Utilized to develop fluorescent tags, affinity labels, and other molecular probes for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	1-Boc-5-Fluoro-3-Indazole-Carboxylic Acid
CAS No.	886368-29-2
Molecular Formula	C₁₃H₁₃FN₂O₄
Molecular Weight	280.25 g/mol
Synonyms	1-Boc-5-Fluoro-1H-indazole-3-carboxylic acid; 5-Fluoro-1-[(tert-butoxy)carbonyl]-1H-indazole-3-carboxylic acid; tert-Butyl 5-fluoro-3-(carboxy)-1H-indazole-1-carboxylate; 1H-Indazole-3-carboxylic acid, 5-fluoro-1-[(1,1-dimethylethoxy)carbonyl]-; 5-Fluoro-1-Boc-indazole-3-carboxylic acid; 1-Boc-5-F-indazole-3-COOH; 886368-29-2; Boc-5-F-Inda-3-COOH
EINECS	Contact for details

Quality Control

Our 1-Boc-5-Fluoro-3-Indazole-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.