Description

2-Biphenyl-3',5'-Difluoro-Carboxylic Acid is a high-purity fluorinated biphenyl carboxylic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its unique molecular architecture, which incorporates fluorine atoms to modulate electronic properties and enhance metabolic stability in target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides where the biphenyl-fluorine motif contributes to bioactivity.
• Liquid Crystal & OLED Materials: Serves as a core structure or side-chain component in the production of advanced electronic display materials.
• Organic Ligand Synthesis: Utilized to create sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorescent Probe Development: Acts as a starting material for synthesizing probes and markers used in biochemical assays and imaging.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and complex molecules under cGMP conditions.

Basic Information

Product Name	2-Biphenyl-3',5'-Difluoro-Carboxylic Acid
CAS No.	886363-21-9
Molecular Formula	C₁₃H₈F₂O₂
Molecular Weight	234.20 g/mol
Synonyms	[2,1';3',1'']Terphenyl-3',5'-difluoro-4'-carboxylic acid; 3',5'-Difluoro-[1,1':2',1''-terphenyl]-4'-carboxylic acid; 2-Biphenyl-3',5'-difluorobenzoic acid; 3',5'-Difluoro-2-phenylbiphenyl-4-carboxylic acid; 4'-Carboxy-3',5'-difluoro-1,1':2',1''-terphenyl
EINECS	Contact for details

Quality Control

Our 2-Biphenyl-3',5'-Difluoro-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent lot-to-lot performance. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements for research or cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.