Description

8-n-Boc-Amino-1,4-Dioxa-Spiro[4.5]Decane-8-Carboxylic Acid is a high-purity, protected amino acid derivative featuring a spirocyclic ketal structure and a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical pharmaceutical intermediate and building block for the synthesis of complex molecules, offering precise control over stereochemistry and functional group manipulation. It is essential for researchers and manufacturers in pharmaceutical development, peptide chemistry, and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used for introducing constrained, cyclic amino acid analogs into peptide chains to modify biological activity and stability.
• Medicinal Chemistry: Serves as a versatile scaffold for constructing spirocyclic and conformationally restricted compounds in drug discovery programs.
• Chemical Biology: Employed in the development of probes and tools for studying biological systems and enzyme mechanisms.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for complex organic molecules.
• Academic & Industrial R&D: A valuable reagent for methodological development and the synthesis of novel chemical entities.

Basic Information

Item	Details
Product Name	8-n-Boc-Amino-1,4-Dioxa-Spiro[4.5]Decane-8-Carboxylic Acid
CAS No.	886362-27-2
Molecular Formula	C14H23NO6
Molecular Weight	301.34 g/mol
Synonyms	8-[(tert-Butoxycarbonyl)amino]-1,4-dioxaspiro[4.5]decane-8-carboxylic acid; 8-(Boc-amino)-1,4-dioxaspiro[4.5]decane-8-carboxylic acid; Boc-8-amino-1,4-dioxaspiro[4.5]decane-8-carboxylic acid; 8-(tert-Butoxycarbonylamino)spiro[4.5]decane-8-carboxylic acid 1,4-dioxa; 8-Amino-1,4-dioxaspiro[4.5]decane-8-carboxylic acid N-Boc derivative; 886362-27-2
EINECS	Contact for details

Quality Control

Our production of 8-n-Boc-Amino-1,4-Dioxa-Spiro[4.5]Decane-8-Carboxylic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.