Description

4-Amino-1-n-Boc-5,7-Dichloro-1,2,3,4-Tetrahydroquinoline is a high-purity, protected tetrahydroquinoline derivative serving as a critical synthetic intermediate. Its value lies in providing a versatile, functionalized scaffold for constructing complex nitrogen-containing heterocycles in advanced pharmaceutical research. This compound is essential for medicinal chemists and process development scientists engaged in the synthesis of novel drug candidates, particularly within therapeutic areas targeting the central nervous system and infectious diseases.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel quinoline-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target engagement.
• Agrochemical Synthesis: Potential intermediate in the development of new crop protection agents and pesticides.
• Academic & Contract Research: Fundamental research reagent in universities and contract research organizations (CROs) for heterocyclic chemistry.

Basic Information

Product Name	4-Amino-1-n-Boc-5,7-Dichloro-1,2,3,4-Tetrahydroquinoline
CAS No.	886362-15-8
Molecular Formula	C₁₄H₁₈Cl₂N₂O₂
Molecular Weight	317.21 g/mol
Synonyms	1-Boc-4-Amino-5,7-dichloro-1,2,3,4-tetrahydroquinoline; tert-Butyl 4-amino-5,7-dichloro-1,2,3,4-tetrahydroquinoline-1-carboxylate; 5,7-Dichloro-1,2,3,4-tetrahydro-4-quinolinamine, 1-[(1,1-dimethylethoxy)carbonyl]-; 4-Amino-5,7-dichloro-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; Boc-4-Amino-5,7-dichloro-THQ; 886362-15-8
EINECS	Contact for details

Quality Control

Our 4-Amino-1-n-Boc-5,7-Dichloro-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.