Description

2,3,4,5,6-Pentafluorophenyl 4-Bromo-2-Chlorobenzenesulfonate is a specialized organosulfur compound featuring a perfluorinated phenyl group and a halogenated benzenesulfonate moiety. This structure makes it a valuable highly reactive electrophilic intermediate and building block in advanced synthetic chemistry. It is primarily utilized by pharmaceutical and agrochemical R&D teams for constructing complex molecules, particularly in nucleophilic aromatic substitution reactions and as a precursor for sulfonamide derivatives.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing sulfonamide or aryl ether functional groups.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the pentafluorophenyl group enhances biological activity and stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, such as sulfonated polymers for membrane technology.
• Ligand and Catalyst Preparation: Employed in organometallic chemistry to create sophisticated ligands for catalysis, leveraging the electron-withdrawing nature of the pentafluorophenyl group.
• Chemical Biology Probes: Useful for labeling biomolecules or creating activity-based probes due to its selective reactivity with nucleophiles like thiols and amines.
• Organic Synthesis Reagent: Acts as a robust sulfonylating agent in multi-step synthetic routes for complex natural products and fine chemicals.

Basic Information

Item	Details
Product Name	2,3,4,5,6-Pentafluorophenyl 4-Bromo-2-Chlorobenzenesulfonate
CAS No.	886361-22-4
Molecular Formula	C12H3BrClF5O3S
Molecular Weight	443.56 g/mol
Synonyms	4-Bromo-2-chlorobenzenesulfonic acid 2,3,4,5,6-pentafluorophenyl ester; Pentafluorophenyl 4-bromo-2-chlorobenzenesulfonate; 4-Bromo-2-chlorobenzene-1-sulfonyl fluoride pentafluorophenyl ester analog; Benzenesulfonic acid, 4-bromo-2-chloro-, 2,3,4,5,6-pentafluorophenyl ester; PFB-CBS; PFP 4-Br-2-Cl-benzenesulfonate
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenyl 4-Bromo-2-Chlorobenzenesulfonate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. Due to its light-sensitive nature, handling should be performed under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.