Description

2,3,4,5,6-Pentafluorophenyl 2,4,6-Triisopropylbenzenesulphonate is a specialized organosulfur reagent featuring a highly activated sulfonate ester group. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in pharmaceutical and advanced material research. It is primarily sought by R&D chemists and process development scientists working on nucleophilic substitution reactions, cross-coupling methodologies, and the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring the introduction of pentafluorophenyl or sulfonate ester functionalities.
• Cross-Coupling Reagent: Used in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) as an electrophilic partner due to its excellent leaving group properties.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials where fluorinated aromatic units are desired.
• Agrochemical Synthesis: Serves as an intermediate in creating novel herbicides, fungicides, and insecticides with enhanced properties.
• Derivatization Agent: Used in analytical chemistry to derivative compounds for improved detection via techniques like GC-MS or LC-MS.
• Chemical Biology Probe Development: Utilized in synthesizing activity-based probes and other tools for studying enzyme function and biological pathways.

Basic Information

Product Name	2,3,4,5,6-Pentafluorophenyl 2,4,6-Triisopropylbenzenesulphonate
CAS No.	886361-20-2
Molecular Formula	C21H21F5O3S
Molecular Weight	448.45 g/mol
Synonyms	Pentafluorophenyl 2,4,6-Triisopropylbenzenesulfonate; 2,4,6-Triisopropylbenzenesulfonic Acid Pentafluorophenyl Ester; PFP 2,4,6-Triisopropylbenzenesulfonate; 2,4,6-Triisopropylphenyl Pentafluorophenyl Sulfonate; Trisyl Pentafluorophenyl Ester; Pentafluorophenyl Trisylate; 886361-20-2; PFP-OTris
EINECS	Contact for details

Quality Control

Our 2,3,4,5,6-Pentafluorophenyl 2,4,6-Triisopropylbenzenesulphonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.