Description

(S)-(Fluoromethyl)-Benzenemethanamine Hydrochloride is a high-purity chiral amine building block, essential for the synthesis of advanced pharmaceutical intermediates. Its value lies in providing a stereochemically defined, fluorinated scaffold that can impart desirable metabolic stability and bioavailability to target molecules. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, especially for central nervous system (CNS) targets.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to explore the impact of fluorinated, chiral amine motifs on potency and selectivity.
• Process Chemistry: Serves as a starting material or intermediate in the scale-up and optimization of synthetic routes for potential APIs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or reagent in enantioselective synthesis to construct complex molecular architectures.
• Agrochemical Research: Potential use in the synthesis of novel, chiral active ingredients for crop protection products.
• Ligand Synthesis: Can be utilized for the preparation of chiral ligands used in catalytic asymmetric transformations.

Basic Information

Product Name	(S)-(Fluoromethyl)-Benzenemethanamine Hydrochloride
CAS No.	886216-59-7
Molecular Formula	C8H11ClFN
Molecular Weight	175.63 g/mol
Synonyms	(S)-1-(Fluoromethyl)benzylamine hydrochloride; (S)-α-(Fluoromethyl)benzylamine hydrochloride; (S)-1-Phenyl-2-fluoroethylamine hydrochloride; (S)-Benzenemethanamine, (fluoromethyl)-, hydrochloride; (S)-Amino(fluoromethyl)phenylmethane hydrochloride; (S)-Fmoc-Protected derivative precursor; Chiral fluorinated benzylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-(Fluoromethyl)-Benzenemethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess (typically >99% ee), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.